ABSTRACT
Objective :To explore mobilizing effect of spironolactone by spironolactone on peripheral blood endothelial progenitor cells (EPCs) in patients with acute myocardial infarction ,and its impact on cardiac function .Methods :A total of 136 patients with acute ST elevation myocardial infarction treated in our department were randomly and e‐qually divided into routine treatment group and spironolactone group (received spironolactone 20mg／time ,once／d based on routine treatment group ) ,both groups were treated for three months .Peripheral blood EPCs level before and 7d after treatment ,cardiac function indexes before and three months after treatment were compared between two groups.Results :After 7d treatment ,peripheral blood EPCs level in spironolactone group was significantly high‐er than that of routine treatment group [ (1. 12 ± 0. 26)% vs.(0.53 ± 0. 14)%, P＝0. 001].Compared with routine treatment group after three‐month treatment ,there was significant rise in LVEF [ (51. 47 ± 8.23)% vs.(56. 52 ± 8.84)%] ,and significant reductions in LVESd [(34. 52 ± 3. 16) mm vs.(32.90 ± 2. 68) mm] and LVEDd [(57. 82 ± 8.13) mm vs.(53. 65 ± 7.22) mm] in spironolactone group , P＜0. 01 all.There was no significant difference in incidence rate of adverse reactions between two groups , P＝0. 595. Conclusion :Spironolactone can significantly in‐crease peripheral blood EPCs level and cardiac function ,and inhibit myocardial remodeling in AMI patients .
ABSTRACT
AIM:To study the type, degree and axial distribution of low vision astigmatism in preschool children.METHODS:A group of 3-6 years old children were selected for astigmatism screening, and statistical analysis was performed on the detected 445 eyes of 308 people.RESULTS:With more than 0.50D astigmatism criteria, astigmatism examination of 308 people, accounting for 36.2%, of which 137 eyes astigmatism, astigmatism 171 monocular.The five types of astigmatism were compound hyperopia 40.7%, mixed 35.5%, compound myopia 8.5%, myopia 8.3%, simple hyperopia astigmatism degree 7.0%;69.0% were mild, 16.6% moderate, 14.4% severe.Astigmatism axial distribution was with the rule for 54.9%, against the rule 28.8%, oblique 16.6%.In binocular astigmatism eyes, axial symmetry was in 35.8%, asymmetry in 64.2%.CONCLUSION:The main type of astigmatism in preschool children are compound hyperopia and mixed astigmatism.Astigmatism degree is mainly mild.With the increase of age, the detection rate of moderate and high astigmatism increased.
ABSTRACT
AIM:To investigate the application of retinal nerve fiber layer (RNFL) thickness detected by OCT in the diagnosis of primary open angle glaucoma (POAG) and its relationship with the mean defect of visual field.METHODS:A retrospective study was carried out.Totally 158 cases (158 eyes) of patients with POAG were selected as POAG group, including 81 cases in early stage, 47 cases in middle stage and 30 cases in late stage.At the same time, 50 cases of persons without eye related diseases were selected as the control group.The upper, lower, nasal and bitamporal RNFL thickness and mean defect of visual field were detected, and the patients with POAG were followed up for 3mo.RESULTS:The upper, lower, nasal and bitamporal RNFL in POAG group were thinner than those in the control, and the mean defect of visual field was higher than that in the control group at different time (P0.05).The RNFL thickness of various parts was higher than that in patients with middle and late POAG, and the mean defect of visual field was lower than that in patients with middle and late POAG (P0.05).Pearson correlation analysis showed that the upper, lower, nasal and bitamporal RNFL thickness was negatively correlated with the mean defect of visual field (r=-0.719,-0.615,-0.681,-0.518, P<0.05).CONCLUSION:OCT can monitor the change of RNFL thickness in patients with POAG, and has a negative correlation with mean defect of visual field, which can be used for early diagnosis of POAG.